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Sildenafil may be used to treat erectile dysfunction (ED or impotence) in men (Viagra brand) or pulmonary arterial hypertension in both men and women (Revatio brand), depending on the brand. Sildenafil blocks the action of an enzyme known as cGMP-specific phosphodiesterase type-5 (PDE-5). buy red viagra usa Viagra Alternatives, Natural Remedies, and Over-the-Counter Options in 2024 Medically reviewed by Philip Ngo, PharmD Written by Jayne Leonard and Kristina Iavarone Updated on Key facts. Sildenafil (Viagra) is a medicine used to treat erectile dysfunction (ED, also called impotence). Sildenafil works by helping to relax the blood vessels in the penis, allowing more blood to flow in and cause an erection.